|Timeline ||Who ||What ||Organism ||Reference |
RJ and Davidson EH ||Proposed that "activator" RNAs
transcribed from redundant genomic regions form complexes with regulatory
DNA sequences to activate a battery of protein coding genes. ||Eukaryotes ||Britten RJ, Davidson EH. Gene regulation for higher cells: a theory Science.
1969 Jul 25;165(891):349-57. |
|1993 ||Ambros Lab |
|Discovered the first microRNA, lin-4 ||C. elegans ||Lee RC, Feinbaum RL, Ambros V.
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense
complementarity to lin-14. Cell. 1993 Dec 3;75(5):843-54. |
Wightman B, Ha I, Ruvkun G.
regulation of the heterochronic gene lin-14 by lin-4 mediates temporal
pattern formation in C. elegans. Cell. 1993 Dec 3;75(5):855-62.
|2000 ||Ruvkun Lab ||Discovered let-7 microRNA ||C. elegans ||
Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE,
Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates
developmental timing in Caenorhabditis elegans. |
Nature. 2000 Feb 24;403(6772):901-6.
|2001 ||Bartel Lab |
|Discovered a large class
of small RNAs with potential regulatory roles and named them microRNA (miRNA) ||C. elegans, |
nvertebrates, and vertebrates
Lau NC, Lim LP, Weinstein EG, Bartel DP. An abundant class of tiny
RNAs with probable regulatory roles in Caenorhabditis elegans. |
Science. 2001 Oct 26;294(5543):858-62.
Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of
novel genes coding for small expressed RNAs. Science. 2001 Oct
Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis
elegans. Science. 2001 Oct 26;294(5543):862-4.
|Bartel Lab ||Discovered microRNA in plants ||Plants ||
Reinhart BJ, Weinstein EG, Rhoades MW, Bartel B, Bartel DP. MicroRNAs
in plants. Genes Dev. 2002 Jul 1;16(13):1616-26. |
Rhoades MW, Reinhart BJ, Lim LP, Burge CB, Bartel B, Bartel DP.
Prediction of plant microRNA targets. Cell. 2002 Aug 23;110(4):513-20.
|2002 ||Croce Lab ||Showed that miRNAs are implicated in
cancer based on the observation that miR15 and miR16 are deleted or downregulated in most
chronic lymphocytic leukemias. ||Human ||
Calin GA, et al. Frequent deletions and down-regulation of micro- RNA
genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl
Acad Sci U S A. 2002 Nov 26;99(24):15524-9. |
|2003 ||Stoffel Lab ||Silenced miRNAs
in vivo using
chemically engineered oligonucleotides, termed 'antagomirs', ||Mammals ||
Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M,
Stoffel M. Silencing of microRNAs in vivo with 'antagomirs'. Nature.
2005 Dec 1;438(7068):685-9.
Vasudevan S et al. ||
First demonstrated that miRNA could activation mRNA
translation ||Human ||
Vasudevan S, Tong Y, Steitz JA.
repression to activation: microRNAs can up-regulate translation.
Science. 2007 Dec 21;318(5858):1931-4. Epub 2007 Nov 29.
Place R, et al. ||
First reported miRNA-mediated transcriptional gene
activation. ||Human ||
Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R.
induces expression of genes with complementary promoter sequences.
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1608-13. Epub 2008 Jan 28.
Kim DH, et al ||
First reported miRNA-induced transcriptional gene
silencing. ||Human ||
Kim DH, Saetrom P, SnÝve O Jr, Rossi JJ.
transcriptional gene silencing in mammalian cells. Proc Natl Acad
Sci U S A. 2008 Oct 21;105(42):16230-5. Epub 2008 Oct 13. |
Zhang L, et al ||
First reported the detection of food-derived exogenous
miRNAs in serum and plasma of animals and cross-kingdom regulation of a
mouse gene by a plant miRNA. ||Human
and Mouse ||
Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian
Z, Liang X, Cai X, Yin Y, Wang C, Zhang T, Zhu D, Zhang D, Xu J, Chen Q,
Ba Y, Liu J, Wang Q, Chen J, Wang J, Wang M, Zhang Q, Zhang J, Zen K,
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence
of cross-kingdom regulation by microRNA. Cell Res. 2012